RESEARCH PROJECTS CURRENTLY ONGOING IN THE LABORATORY:
IMM-GNRs, CALL MSCA IF Horizon 2020 (2018-2019)
As Overall Goal IMM-GNRs intends to overcome the aforementioned limits of conventional nano-immunotoxicology approaches. IMM-GNRs will provide a comprehensive and quantitative picture of the GNRs immune activity in relation to their structural properties (shape, edge structures, width, size, molecular weight).
CARBO-IMmap, CALL RISE under Horizon 2020 (2017-2021)
The CARBO-IMmap project major aim is to advance the field of carbon nanomaterial development and their exploitation biomedical applications. The long-range goal of Carbo-IMmap is to develop a functional pipeline for the immune-characterization of carbon nanomaterials, for the qualitative and quantitative assessment in vitro and ex vivo of the human immune compatibility and immune activity of newly developed carbon materials.
The program will enable long-term, transformative research collaborations that will contribute to the integration and collaboration of research groups of 4 European Countries (Germany, Italy, France and Spain) and 3 key non-EU Countries: USA, China and Qatar.
Multifunctional nanotool for advanced cancer diagnostics, PRIN 2016 under the Italian MIUR (2017-2020)
G-IMMUNOMICS, call FlagERA 2015 under Horizon 2020 (2016-2019)
Graphene is the most promising, versatile, and sustainable key enabling nanotechnology which may bring solutions in the near future to many areas spanning materials science and medicine.
The overall objective of G-IMMUNOMICS is to complement Flagship research on graphene safety with immunogenomic and proteomic data, not covered by the Core Project. G-IMMUNOMICS will provide new insights on the immune impact of several types of graphene to lay the basis for a safe use of graphene and the graphene technology future transfer in medicine. The specific objectives are:
1- Produce highly stable and dispersible pristine and functionalized graphene family materials (GFMs) with different lateral size and appropriate functionalizations
2- Characterize by high throughput functional immunogenomics and proteomics approaches and genotoxic assays the immune cell response induced by GFMs on different cell lines and primary cell.
3- Evaluate the immune cell response induced by GFMs on four different species: human, mouse, pig and worm.
G-NANOULTRA: Graphene as a new nanocontrast agent for cancer ultrasonography diagnosis and therapy
Ultrasonography (US) is used in every day clinical practice. Current US contrast agents (USCAs) are exclusively diagnostic tools. We showed great potential of carbon nanomaterials as USCAs (Delogu LG et al PNAS 2012). The project G-NANOULTRA is based on a solid international network of collaborations and the expertise in nanobiotechnology of the PI. We aim at develop new carbon USCAs based on graphene with multiple functions such as: cancer diagnosis, immunotherapy and fast drug delivery.